Week 6 is set. Below are our game-by-game predictions for the full slate with the current spread, our pick for every game, the upsets we like, a few best bets, and the storylines worth watching. Lines come from our Week 6 pick’em with odds sheet; grab the printable pick sheet below to fill in your own. Four teams are on bye (Bengals, Lions, Dolphins, Vikings), so pools run 14 games.
Quick Facts
- Slate: Thursday, October 15 through Monday, October 19 (14 games)
- Marquee games: Texans at Jaguars in London (Wembley, 9:30 am ET), Cowboys at Packers (SNF), Commanders at 49ers (MNF)
- Our upset picks: Steelers at Tampa Bay and Chargers at Kansas City
- On bye: Bengals, Lions, Dolphins, Vikings
- Printable: a game-by-game pick sheet is below
Week 6 Predictions: Every Game
| Matchup | Spread | Our pick |
|---|---|---|
| Seahawks at Broncos (TNF) | Seahawks -1.5 | Seahawks |
| Texans at Jaguars (London) | Jaguars -1.5 | Jaguars |
| Ravens at Browns | Ravens -6.5 | Ravens |
| Panthers at Eagles | Eagles -6.5 | Eagles |
| Bears at Falcons | Bears -3.5 | Bears |
| Saints at Giants | Giants -2.5 | Giants |
| Jets at Patriots | Patriots -9.5 | Patriots |
| Steelers at Buccaneers | Buccaneers -1.5 | Steelers (upset) |
| Titans at Colts | Colts -3.5 | Colts |
| Cardinals at Rams | Rams -13.5 | Rams |
| Bills at Raiders | Bills -6.5 | Bills |
| Chargers at Chiefs | Chiefs -2.5 | Chargers (upset) |
| Cowboys at Packers (SNF) | Packers -3.5 | Packers |
| Commanders at 49ers (MNF) | 49ers -5.5 | 49ers |
Upset Watch
Steelers at Buccaneers. Tampa Bay is only a 1.5-point home favorite, which is close to a coin flip. Pittsburgh’s defense travels well, and we like the Steelers to win this one outright.
Chargers at Chiefs. A 2.5-point home number in a division game is thin. The Chargers have the arm talent to hang in Kansas City; give us Los Angeles for the outright upset.
Best Bets and Leans
- Bills -6.5 at Las Vegas. Buffalo is a class above a reeling Raiders side; we lean the Bills to cover on the road.
- Under 42.5 in Texans at Jaguars. The lowest total on the board and a 9:30 am London kickoff between two defense-first teams.
- Over 51.5 in Cowboys at Green Bay. The highest total of the week, with Dallas’s pace meeting a Packers offense that scores at home.
Picks and leans are for entertainment. Lines move, so check the live numbers on our pick’em sheet, and if you play, play responsibly.
Storylines to Watch
Week 6 opens overseas, with the Texans and Jaguars meeting at Wembley in the 9:30 am ET London window before a full wave of 1 pm kickoffs. Rams -13.5 over Arizona is the steepest number on the board, and Patriots -9.5 over the Jets is next. Sunday night sends the Cowboys to Green Bay in the highest-total game of the week (51.5), and Monday closes with the Commanders at the 49ers. For where to watch every game by market, see our Week 6 TV coverage map.
Printable Week 6 Pick Sheet
Download the free printable pick sheet: every game with the spread, the over/under total, and blank columns for your pick and predicted score. Perfect for an office pool.
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Frequently Asked Questions
What are the best Week 6 upset picks?
We like the Steelers to win outright at Tampa Bay and the Chargers to pull the upset at Kansas City, both in games with spreads inside a field goal.
Where do the spreads come from?
The lines on this page are pulled from our Week 6 pick’em with odds sheet and are current as of publish. Numbers move during the week, so check that page for the latest.
Which teams are on a bye in Week 6?
Cincinnati, Detroit, Miami, and Minnesota are off in Week 6, so pick’em pools run 14 games.
Is there a printable pick sheet?
Yes. Use the download button above for a one-page sheet with every game, the spread, the total, and blank pick and score columns.
Last updated: October 12, 2026.
