Last updated: September 7, 2026. The 2026 NFL Week 2 pick’em is here, and this version comes with the betting lines: point spread and over/under total for all 16 games. Print the sheet, circle your picks against the spread, and run a pool with friends. The numbers below are look-ahead lines as of September 7, 2026; Week 2 spreads move sharply once Week 1 is in the books, so treat them as a starting point. We refresh this page with the firmed lines (and moneylines) after Week 1 wraps on Monday, September 14.
2026 NFL Week 2 Pick’em: Quick Facts
- Week: NFL Week 2, September 17-21, 2026
- Games: 16 (opens Thursday, Sept 17, Lions at Bills)
- Includes: point spread and over/under total for every game
- Lines: look-ahead spreads as of September 7, 2026, refreshed after Week 1
- Use it for: against-the-spread pools and pick’em contests
2026 NFL Week 2 Odds: Spreads and Totals
Every Week 2 matchup is shown with the current look-ahead line. The home team is listed second, and the spread names the favorite. Because these are early numbers posted before Week 1 is played, expect movement once results, injuries, and betting action come in; check a current sportsbook before you lock in a pool.
| DATE | MATCHUP (AWAY AT HOME) | SPREAD | O/U |
|---|---|---|---|
| Thu Sep 17 | Detroit Lions at Buffalo Bills | Bills -3 | 52.5 |
| Sun Sep 20 | Carolina Panthers at Atlanta Falcons | Falcons -1.5 | 43.5 |
| Sun Sep 20 | Minnesota Vikings at Chicago Bears | Bears -3.5 | 45.5 |
| Sun Sep 20 | Philadelphia Eagles at Tennessee Titans | Eagles -4.5 | 42.5 |
| Sun Sep 20 | Pittsburgh Steelers at New England Patriots | Patriots -4.5 | 43.5 |
| Sun Sep 20 | Green Bay Packers at New York Jets | Packers -6.5 | 42.5 |
| Sun Sep 20 | Cleveland Browns at Tampa Bay Buccaneers | Buccaneers -6.5 | 42.5 |
| Sun Sep 20 | New Orleans Saints at Baltimore Ravens | Ravens -7.5 | 46.5 |
| Sun Sep 20 | Cincinnati Bengals at Houston Texans | Texans -2.5 | 46.5 |
| Sun Sep 20 | Jacksonville Jaguars at Denver Broncos | Broncos -2.5 | 43.5 |
| Sun Sep 20 | Las Vegas Raiders at Los Angeles Chargers | Chargers -3 | 44.5 |
| Sun Sep 20 | Washington Commanders at Dallas Cowboys | Cowboys -4.5 | 51.5 |
| Sun Sep 20 | Seattle Seahawks at Arizona Cardinals | Seahawks -10 | 44.5 |
| Sun Sep 20 | Miami Dolphins at San Francisco 49ers | 49ers -10.5 | 46.5 |
| Sun Sep 20 | Indianapolis Colts at Kansas City Chiefs | Chiefs -5.5 | 47.5 |
| Mon Sep 21 | New York Giants at Los Angeles Rams | Rams -9.5 | 47.5 |
What the Week 2 Lines Are Telling Us
The board opens with three double-digit favorites: the San Francisco 49ers (-10.5) at home against Miami, the Seattle Seahawks (-10) on the road in Arizona, and the Los Angeles Rams (-9.5) hosting the Giants on Monday night. The biggest number on a road team is Seattle, a rare double-digit away spread that will be worth watching as the week develops.
For totals, the Thursday opener between Detroit and Buffalo tops the slate at 52.5, followed by the NFC East clash of Washington at Dallas at 51.5, both signaling shootout expectations. At the other end, a cluster of games sits at 42.5 (Steelers-Patriots, Packers-Jets, Browns-Buccaneers, Eagles-Titans), so those are the spots the market sees playing low and slow. The tightest spreads, Falcons -1.5 and the near pick’em games, are the ones most likely to swing after Week 1.
How to Run a Week 2 Pick’em Pool
Print one sheet per player. Each person circles the team they think will cover the spread in every game (and optionally the over or under). Score one point per correct pick against the spread; the most points wins the week. For a tiebreaker, have players guess the total combined points in the Monday night game, New York Giants at Los Angeles Rams. Because these are look-ahead lines, you can also lock your pool to the numbers on this sheet so everyone plays the same spreads all week.
More 2026 NFL Resources
- 2026 NFL Weekly Schedule Hub: All Pick’em Sheets, TV Guide & PDF Grids
- 2026 NFL Week 2 Schedule: Matchups, Kickoff Times & TV Guide
- 2026 NFL Week 1 Pick’em with Odds: Spreads & Totals
- NFL Kickoff Times This Week in Pacific Time (PT) & TV
- 2026 NFL Standings
2026 NFL Week 2 Pick’em: FAQ
What are the Week 2 odds based on?
These are look-ahead lines posted before Week 1 is played, captured on September 7, 2026. Sportsbook numbers move with results, injuries, weather, and betting action, so confirm the current line before wagering. We refresh the spreads on this page after Week 1.
What does the spread mean?
The spread is the margin the favorite must win by to cover. For example, Bills -3 means Buffalo must win by four or more to cover; a Lions pick covers if Detroit loses by two or fewer, or wins outright.
When is the Week 2 Monday Night Football game?
Week 2 Monday Night Football is New York Giants at Los Angeles Rams, Monday, September 21 at 8:15 PM ET on ESPN and ABC.
Is the Week 2 pick’em sheet free?
Yes. The printable Week 2 pick’em sheet with odds is a free PDF you can download at the top of this page, print, and run in your pool.
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