See also: 2026 NFL Week 2 Predictions for our pick on every game against the spread, an upset watch, and best bets.
Last updated: September 15, 2026. The 2026 NFL Week 2 pick’em is here with the firmed betting lines: point spread, over/under total, and moneyline for all 16 games. Print the sheet, circle your picks against the spread, and run a pool with friends. These are the locked-in Week 2 numbers, refreshed after Week 1 wrapped on Monday, September 14; several spreads swung hard off the look-ahead board, so scan the table below before you set your pool.
2026 NFL Week 2 Pick’em: Quick Facts
- Week: NFL Week 2, September 17-21, 2026
- Games: 16 (opens Thursday, Sept 17, Lions at Bills)
- Includes: point spread, over/under total, and moneyline for every game
- Lines: firmed spreads, totals and moneylines, updated September 15, 2026
- Use it for: against-the-spread pools and pick’em contests
2026 NFL Week 2 Odds: Spreads, Totals and Moneylines
Every Week 2 matchup is shown with its firmed line, now including the moneyline. The home team is listed second, and the spread names the favorite. These numbers locked in after Week 1, but they can still shift on late injury news, so check a current sportsbook before you lock in a pool.
| DATE | MATCHUP (AWAY AT HOME) | SPREAD | O/U | ML (Away/Home) |
|---|---|---|---|---|
| Thu Sep 17 | Detroit Lions at Buffalo Bills | Bills -4.5 | 53.5 | +190 / -225 |
| Sun Sep 20 | Carolina Panthers at Atlanta Falcons | Panthers -1.5 | 44.0 | -115 / -105 |
| Sun Sep 20 | Cincinnati Bengals at Houston Texans | Texans -3.5 | 46.5 | +135 / -155 |
| Sun Sep 20 | Cleveland Browns at Tampa Bay Buccaneers | Buccaneers -9.5 | 41.0 | +330 / -420 |
| Sun Sep 20 | Green Bay Packers at New York Jets | Packers -3.5 | 45.0 | -200 / +175 |
| Sun Sep 20 | Minnesota Vikings at Chicago Bears | Bears -5.5 | 49.5 | +205 / -245 |
| Sun Sep 20 | New Orleans Saints at Baltimore Ravens | Ravens -9.5 | 47.0 | +335 / -425 |
| Sun Sep 20 | Philadelphia Eagles at Tennessee Titans | Eagles -7.5 | 39.0 | -340 / +275 |
| Sun Sep 20 | Pittsburgh Steelers at New England Patriots | Patriots -5.5 | 41.5 | +200 / -240 |
| Sun Sep 20 | Jacksonville Jaguars at Denver Broncos | Broncos -0.5 | off | -105 / -105 |
| Sun Sep 20 | Las Vegas Raiders at Los Angeles Chargers | Chargers -7.5 | 43.5 | +265 / -325 |
| Sun Sep 20 | Miami Dolphins at San Francisco 49ers | 49ers -13.5 | 45.0 | +635 / -950 |
| Sun Sep 20 | Seattle Seahawks at Arizona Cardinals | Seahawks -4.5 | 41.0 | -210 / +180 |
| Sun Sep 20 | Washington Commanders at Dallas Cowboys | Cowboys -3.5 | 50.5 | +170 / -195 |
| Sun Sep 20 | Indianapolis Colts at Kansas City Chiefs | Chiefs -0.5 | off | -105 / -105 |
| Mon Sep 21 | New York Giants at Los Angeles Rams | Rams -7.5 | 48.5 | +270 / -335 |
What the Week 2 Lines Are Telling Us
The steepest number on the Week 2 board is San Francisco 49ers (-13.5) at home against Miami Dolphins, with Tampa Bay Buccaneers (-9.5) and Baltimore Ravens (-9.5) the next-biggest favorites. Totals top out at 53.5 in Detroit Lions at Buffalo Bills, a shootout number, while Philadelphia Eagles at Tennessee Titans anchors the low end at 39.0. The closest calls, Panthers at Falcons, Jaguars at Broncos, Colts at Chiefs, are the games most likely to move before kickoff. Sharpest shifts off the look-ahead: Kansas City slid from -5.5 all the way to a virtual pick’em (-0.5) against Indianapolis, Seattle dropped from -10 to -4.5 at Arizona, and the Chargers jumped from -3 to -7.5 over the Raiders, while San Francisco climbed to -13.5 at home against Miami. Totals on the Colts-Chiefs and Jaguars-Broncos games are off the board for now on injury news.
How to Run a Week 2 Pick’em Pool
Print one sheet per player. Each person circles the team they think will cover the spread in every game (and optionally the over or under). Score one point per correct pick against the spread; the most points wins the week. For a tiebreaker, have players guess the total combined points in the Monday night game, New York Giants at Los Angeles Rams. Because these are look-ahead lines, you can also lock your pool to the numbers on this sheet so everyone plays the same spreads all week.
More 2026 NFL Resources
- 2026 NFL Weekly Schedule Hub: All Pick’em Sheets, TV Guide & PDF Grids
- 2026 NFL Week 2 Schedule: Matchups, Kickoff Times & TV Guide
- 2026 NFL Week 1 Pick’em with Odds: Spreads & Totals
- NFL Kickoff Times This Week in Pacific Time (PT) & TV
- 2026 NFL Standings
2026 NFL Week 2 Pick’em: FAQ
What are the Week 2 odds based on?
These are the firmed Week 2 lines, refreshed September 15, 2026 after Week 1, from an aggregate of major sportsbooks. Numbers can still move on late injury and betting action, so confirm the current line before wagering.
What does the spread mean?
The spread is the margin the favorite must win by to cover. For example, Bills -3 means Buffalo must win by four or more to cover; a Lions pick covers if Detroit loses by two or fewer, or wins outright.
When is the Week 2 Monday Night Football game?
Week 2 Monday Night Football is New York Giants at Los Angeles Rams, Monday, September 21 at 8:15 PM ET on ESPN and ABC.
Is the Week 2 pick’em sheet free?
Yes. The printable Week 2 pick’em sheet with odds is a free PDF you can download at the top of this page, print, and run in your pool.
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