The 2025 NFL Week 1 odds are out. The season kicks off on Thursday, September 4th, and includes a mix of divisional rivalries, international matchups, and some early season, high-stakes games. There are 16 games spread across Thursday, Friday, Sunday, and Monday, with betting lines reflecting early-season uncertainties and team changes. Everything listed is notional and subject to change based on current events, sportsbooks, and more. Nothing included is financial or betting advice, but provided to help you enjoy the games more.
NFL Week 1 Highlighted Games
- Dallas Cowboys at Philadelphia Eagles (Thursday, Sept. 4, 8:20 p.m. ET): The Eagles, bolstered by a strong offseason, open as 7-point favorites in this NFC East clash. With a moneyline of -245 for Philly and an over/under of 45.5, expect fireworks from two potent offenses.
- Kansas City Chiefs at Los Angeles Chargers (Friday, Sept. 5, 8 p.m. ET, São Paulo, Brazil): In the NFL’s first South American game, the defending champs are 3-point favorites (-170 ML). The total sits at 45.5, hinting at a potential shootout between Patrick Mahomes and Justin Herbert.
- Baltimore Ravens at Buffalo Bills (Sunday, Sept. 7, 8:20 p.m. ET): This Sunday Night Football showdown is nearly a pick’em, with Buffalo favored by 1.5 (-125 ML). At 50.5, the highest total of the week suggests a high-scoring affair between Lamar Jackson and Josh Allen.
- Minnesota Vikings at Chicago Bears (Monday, Sept. 8, 8:15 p.m. ET): The Bears edge out as 1.5-point home favorites (-120 ML) in this NFC North battle. With a low total of 43.5, defense could dominate early-season rust.
Other fun week 1 lines include close contests like the Detroit Lions at Green Bay Packers (Packers -1.5) and San Francisco 49ers at Seattle Seahawks (49ers -1.5).
2025 NFL Week 1 Odds Table
Here’s the 2025 NFL Week 1 odds table for you. It includes the spread, moneyline, and over/under for the game. You can also checkout our week 1 pick-em sheet that does not include the odds here for the games. Our NFL Week 1 preview podcast is up here for you to enjoy as well.
| Game (Away @ Home) | Spread | Moneyline | Over/Under |
| Cowboys @ Eagles | Eagles -7 | Eagles -245 / Cowboys +215 | 45.5 |
| Chiefs @ Chargers | Chiefs -3 | Chiefs -170 / Chargers +310 | 45.5 |
| Steelers @ Jets | Steelers -2.5 | Steelers -155 / Jets -142 | 38.5 |
| Dolphins @ Colts | Colts -1.5 | Colts -108 / Dolphins +100 | 47.5 |
| Panthers @ Jaguars | Jaguars -3.5 | Jaguars +136 / Panthers +140 | 46.5 |
| Giants @ Commanders | Commanders -7.5 | Commanders -245 / Giants +215 | 45.5 |
| Bengals @ Browns | Bengals -4.5 | Bengals -245 / Browns +270 | 47.5 |
| Raiders @ Patriots | Patriots -3.5 | Patriots -285 / Raiders +140 | 42.5 |
| Cardinals @ Saints | Cardinals -3.5 | Cardinals -192 / Saints +140 | 43.5 |
| Buccaneers @ Falcons | Buccaneers -2.5 | Buccaneers -142 / Falcons +295 | 46.5 |
| Titans @ Broncos | Broncos -7.5 | Broncos -135 / Titans +300 | 42.5 |
| 49ers @ Seahawks | 49ers -1.5 | 49ers -135 / Seahawks -120 | 44.5 |
| Lions @ Packers | Packers -1.5 | Packers -102 / Lions +124 | 47.5 |
| Texans @ Rams | Rams -3.5 | Rams -121 / Texans +120 | 43.5 |
| Ravens @ Bills | Bills -1.5 | Bills -125 / Ravens +102 | 50.5 |
| Vikings @ Bears | Bears -1.5 | Bears -120 / Vikings +102 | 43.5 |
Week 1 often brings surprises, so consider factors like injuries and rookie performances. Bet responsibly and enjoy the season!
2025 NFL Preseason and Regular Season Schedules
We have all of the 2025 NFL regular season schedules posted for you to enjoy. You can also checkout all of the individual team schedules (Regular Season) below as well as the 2026 NFL Playoff bracket and Super Bowl Schedule .
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